The latest as well as archived research items on diabetes medical advances and studies.

August 2010

Groundbreaking wireless sensor will monitor diabetics' glucose levels from the INSIDE


"Dead in bed": a tragic complication of type 1 diabetes mellitus.

Confirmation of hypoglycemia in the "dead-in-bed" syndrome, as captured by a retrospective continuous glucose monitoring system.

July 2010

ADA: Sensor-Augmented Insulin Pump Therapy Wins Over Multiple Daily Injections for Type 1's

ADA: Continuous Glucose Monitoring Only Successful with Knowledge and Support

June 2010

Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study

Enhanced Accuracy of Continuous Glucose Monitoring by Online Extended Kalman Filtering

The importance of glycemic control: how low should we go with HbA1c? Start early, go safe, go low

May 2010

April 2010

March 2010

February 2010

Artificial Pancreas System Helps Control Nighttime Hypoglycemia

Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial

Approval of Diamyd's Diabetes Vaccine Set for 2011

Ethnic Differences in Incidence of Type 1 Diabetes among Second-Generation Immigrants and Adoptees from Abroad

January 2010

Missed Insulin Boluses for Snacks in Youth with Type 1 Diabetes

Up to 10% of Children with Type 1 Diabetes have Celiac Disease

Progression to diabetes in relatives of type 1 diabetic patients: mechanisms and mode of onset.

JDRF Announces Diabetes Research Program with Johnson & Johnson

Diamyd Medical gets OK from FDA to test diabetes vaccine on small children

Association Of Tight Glycemic Control With Road Crashes In Diabetic Patients

November 2009

Sudden death in type 1 diabetes: The mystery of the ‘dead in bed’ syndrome

Variable A1C Linked to Renal Disease in Type 1 Diabetes

Cardiovascular Risk in Youth With Type 1 Diabetes Linked Primarily to Insulin Resistance

Transition to Adult Care for Youths With Diabetes Mellitus: Findings From a Universal Health Care System

The effect of biopsy-positive silent coeliac disease and treatment with a gluten-free diet on growth and glycaemic control in children with Type 1 diabetes

Psychological symptoms and insulin sensitivity in adolescents

Age at onset of Type 1 Diabetes in Parents and Recurrence risk in offspring

October/November 2009

A Pilot Trial of Pramlintide Home Usage in Adolescents With Type 1 Diabetes

Closed-Loop Insulin Delivery Using a Subcutaneous Glucose Sensor and Intra-Peritoneal Insulin Delivery: A Feasibility Study Testing a New Model for the Artificial Pancreas.

Brief Report: Parent's Health Literacy among High-Risk Adolescents with Insulin Dependent Diabetes

Pancreas transplantation alone in children: a case report.

September 2009

Accuracy and Reliability of Continuous Glucose Monitoring in Individuals with Type 1 Diabetes During Recreational Diving

Retinal Vascular Fractal Dimension and Risk of Early Diabetic Retinopathy: A Prospective Study of Children and Adolescents with Type 1 Diabetes

Association of type 1 diabetes with month of birth among US youth: The SEARCH for Diabetes in Youth Study

August 2009

Discovery Of A Gene That May Play A Role In Type 1 Diabetes

Chicago Diabetes Project

Predictors of Insulin Regimens and Impact on Outcomes in Youth with Type 1 Diabetes: The SEARCH for Diabetes in Youth Study

The effectiveness of glucose, sucrose, and fructose in treating hypoglycemia in children with type 1 diabetes

Low dose (0.05 units/kg/h) is comparable with standard dose (0.1 units/kg/h) intravenous insulin infusion for the initial treatment of diabetic ketoacidosis in children with type 1 diabetes-an observational study.

Continuous glucose monitoring in youth with type 1 diabetes.

June and July 2009

Inpatient care of patients with type 1 diabetes mellitus by duration of diabetes and sex: A nationwide population-based longitudinal study

Reducing glycaemic variability in type 1 diabetes self-management with a continuous glucose monitoring system based on wired enzyme technology

Exubera Inhaled Insulin in Patients with Type 1 and Type 2 Diabetes: The First 12 Months

May 2009

The link between type 1 diabetes and celiac disease

Comparison of a Multiple Daily Insulin Injection Regime (Basal Once-Daily Glargine plus Mealtime Lispro) and CSII (Lispro) in Type 1 Diabetes: a Randomized Open Parallel Multicenter Study

Institution of Basal-Bolus Therapy at Diagnosis for Children With Type 1 Diabetes Mellitus

Cognitive Function is Disrupted by Both Hypo- and Hyperglycemia in School-Aged Children with type 1 diabetes: A Field Study

Electronic Device For Quick And Painless Glucose Test To Aid Diabetics Designed By Biomedical Engineers At University Of Calgary

Patients With Type 1 Diabetes May Get Cure From Stem Cells

April 2009

Prevalence and Correlates of Depression in Individuals With and Without Type 1 Diabetes

Antibiotic Use and Type 1 Diabetes in Childhood

Next-Generation Sequencing Uncovers Genetic Variation Linking Type 1 Diabetes With Enterovirus Infection

March 2009

New Study Of Human Pancreases Links Virus To Cause Of Type 1 Diabetes - May Lead To A Vaccine

Low-glycaemic index sweetener-based beverages reduce 24-h glucose profiles in healthy adults

Effect of popular takeaway foods on blood glucose levels in type 1 diabetes mellitus patients on intensive insulin therapy.

January/February 2009

Explaining the Adjustment of Adolescents with Type 1 Diabetes: The Role of Diabetes-Specific and Psychosocial Factors

Missed bolus doses: devastating for metabolic control in CSII-treated adolescents with type 1 diabetes

Changing basal insulin from NPH to detemir or glargine in patients with type 1 diabetes and a history of severe hypoglycemia

Improved glycaemic control by switching from insulin NPH to insulin glargine: a retrospective observational study

Encapsulated porcine islet transplantation: an evolving therapy for the treatment of type I diabetes.

Current status of islet cell transplantation.

A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes.

December 2008

Hypoglycemia with intensive insulin therapy. A systematic review and meta-analyses of randomized trials of continuous subcutaneous insulin infusion versus multiple daily injections

Breakthrough In Understanding Development Of Type 1 Diabetes

Cancer Drug Could Help Diabetics

No benefit for nasal insulin in preventing, delaying type 1 diabetes

New Study Finds Changes In Position Of Conventional Insulin Pumps Can Cause Fluctuations In Insulin Delivery Rates

November 2008

Psychological Therapy to Improve Control of Type 1 Diabetes

Diabetes Type 1 Vaccine - Diamyd(R) Phase III Study Approved By Six European Countries

Study Looks At Impact Of Insulin Pump

Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes—the ‘dead in bed’ syndrome revisited

Type 1 Diabetes May Be Based on Gene-Expression Signatures rather than Specific Variants

Relationship between beta-cell mass and diabetes onset.

Lessons learned from studies of the natural history of diabetic nephropathy in young type 1 diabetic patients.

Hypoglycemia 

October 2008

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

Type 1 Diabetes May Result From Good Genes Behaving Badly

New Zealand to trial pig cells as treatment for type 1 diabetes

September 2008

'Friendly' Bacteria Protect Against Type 1 Diabetes, Yale Researchers Find

Pre-meal blood sugar values most informative: study

New Study Demonstrates Glucose Device Rapidly Alleviates Major Symptom Of Type 1 Diabetes In Children

A Study Assessing an Injection Port for Administration of Insulin 

Devise to Control Blood Sugar Benefits Type 1 Diabetes Patients

Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time 

August 2008

A novel insulin formulation with a more rapid onset of action

Insulin Glargine Versus Intermediate-Acting Insulin as the Basal Component of Multiple Daily Injection Regimens for Adolescents with Type 1 Diabetes Mellitus.

July 2008

Effects of inhaled human insulin on airway lining fluid composition in adults with diabetes

Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes

LCT Informed Of Progress For Decision On Diabetes Clinical Trial In New Zealand

Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison 

Unique Drug Combination May Hold The Key To Reversing Type I Diabetes

June 2008

Unique drug combination may hold the key to reversing Type I diabetes

Vitamin D May Cut Risk Of Type 1 Diabetes. Babies, Children Should Be Given Vitamin D Supplements, Researchers Say 

Insulin Glargine Maintains Equivalent Glycemic Control and Better Lipometabolic Control than NPH Insulin in Type 1 Diabetes Patients Who Missed a Meal

Type 1 Diabetes In Finnish Children Skyrockets

Islet Cell Transplants Aid Type 1 Diabetics.  Study participants lived insulin-free for at least a year or two

May 2008

Evidence Discovered For Suspected Cause Of Type 1 Diabetes

Acute Complications and Drug Misuse Are Important Causes of Death for Children and Young Adults With Type 1 Diabetes

Blood pressure in diabetic kids needs watching

Discovery Leads to Earlier Diagnosis of Type 1 Diabetes.  Researchers identify molecular signature in human type 1 diabetes 

Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitus

April 2008

Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy. 

Hyperglycaemia as a determinant of cognitive decline in patients with type 1 diabetes.

The impact of an assisted diabetes care programme on a private practice

Are family factors universally related to metabolic outcomes in adolescents with Type 1 diabetes?

Prevalence of impaired awareness of hypoglycaemia in adults with Type 1 diabetes

Long-term efficacy and safety of insulin detemir compared to Neutral Protamine Hagedorn insulin in patients with Type 1 diabetes using a treat-to-target basal–bolus regimen with insulin aspart at meals: a 2-year, randomized, controlled trial

Measurement of Insulin Sensitivity in Children.  Comparison between the euglycemic-hyperinsulinemic clamp and surrogate measures  

Time series analysis of ultraviolet B radiation and type 1 diabetes in Newfoundland

Improved glycemic control and lower frequency of severe hypoglycemia with insulin detemir; long-term experience in 105 children and adolescents with type 1 diabetes

Very high and increasing incidence of type 1 diabetes mellitus in Newfoundland and Labrador, Canada

March 2008

Phosphagenics Initiates Its Phase 2 Clinical Trial In Type 1 Diabetes

Perinatal risk factors for early childhood onset type 1 diabetes in Austria – a population-based study (1989–2005)

Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator) 

Teenagers with type 1 diabetes—a phenomenological study of the transition towards autonomy in self-management

Age-specific Characteristics of the Basal Insulin-rate for Pediatric Patients on CSII

Sensor-augmented pump therapy in type 1 diabetes.

Human Insulin Analog–Induced Lipoatrophy

Relationship of A1C to Glucose Concentrations in Children With Type 1 Diabetes

Quality of life and treatment satisfaction in adults with Type 1 diabetes: a comparison between continuous subcutaneous insulin infusion and multiple daily injections

Hypoglycemia in Type 1 Diabetes. A still unresolved problem in the era of insulin analogs and pump therapy

Long-Acting Insulin Analogs Versus Insulin Pump Therapy for the Treatment of Type 1 and Type 2 Diabetes

February 2008

Quality of life and treatment satisfaction in adults with Type 1 diabetes: a comparison between continuous subcutaneous insulin infusion and multiple daily injections Study suggests quality of life gains deriving from greater lifestyle flexibility, less fear of hypoglycaemia, and higher treatment satisfaction, when CSII is compared with either glargine-based or NPH-based MDI regimens.

Fully Automated Closed-Loop Insulin Delivery vs. Semi-Automated Hybrid Control in Pediatric Patients with Type 1 Diabetes using an Artificial Pancreas

Basal insulin switch from NPH to glargine in children and adolescents with type 1 diabetes

Very high and increasing incidence of type 1 diabetes mellitus in Newfoundland and Labrador, Canada.

Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?

Transplanted Pig Cell Islets: A Solution For Diabetes Sufferers? USA

High prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes: a population-based study.

Comparison of continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) in paediatric Type 1 diabetes: a multicentre matched-pair cohort analysis over 3 years.

January 2008

Detection of a Meal Using Continuous Glucose Monitoring (CGM): Implications for an Artificial β-cell 

Pig Islet Cells: The Solution For Diabetes?

The role of partner relationships in the young person's adherence to the diabetes self-care regime.

International Initiative To Study Viruses Implicated In Type I Diabetes Launched In London

A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland

December 2007

Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study.

Hospital admission patterns subsequent to diagnosis of type 1 diabetes in children : a systematic review

Delayed recovery of cognitive function following hypoglycemia in adults with type 1 diabetes: effect of impaired awareness of hypoglycemia

Mean blood glucose compared with HbA(1c) in the prediction of cardiovascular disease in patients with type 1 diabetes

Insulin glargine improves fasting blood glucose levels in prepubertal children with unsatisfactorily controlled type 1 diabetes 

Seasonality of month of birth differs between type 1 diabetes patients with pronounced beta-cell autoimmunity and individuals with lesser or no beta-cell autoimmunity. 

Defining the role of insulin detemir in Basal insulin therapy. 

November 2007

A morning dose of insulin glargine prevents nocturnal ketosis after postprandial interruption of continuous subcutaneous insulin infusion with insulin lispro. 

Continuous subcutaneous insulin infusion benefits quality of life in preschool-age children with type 1 diabetes mellitus 

October 2007

Statins May Benefit Kids With Recalcitrant Lipids New recommendations point to drug therapy when dietary change fails 

The Effect of Cinnamon on Glucose Control and Lipid Parameters

Diabetic Breath Analysis Offers Potential For Noninvasive Blood Sugar Monitoring

New sources of pancreatic beta cells

The International Diabetes Federation (IDF) Recommends Tighter Control Of Blood Glucose Levels After Meals In People With Diabetes

New Data Supports Long-Term Efficacy And Safety In Patients Who Took Exubera For Eight Years

August and September 2007

Predictors of cognitive impairment in type 1 diabetes.

Alba Therapeutics Announces IND For Beta Cell Preservation In Type 1 Diabetes Using AT-1001

Inhaled Insulin Shows Short-term Safety
New studies assuage some concerns, but long-term effects still uncertain

The association of early atherosclerosis and retinopathy in adolescents with type 1 diabetes: preliminary report.

Hyperglycemia and Externalizing Behavior in Children With Type 1 Diabetes

Continuing Stability of Center Differences in Pediatric Diabetes Care: Do Advances in Diabetes Treatment Improve Outcome?

The influence of long-term therapy with the insulin pump (CSII) in patients with type 1 diabetes mellitus on metabolic compensation and on the incidence of hypoglycaemia. Comparison with intensified
conventional insulin therapy (MDI).
 

Researchers Focus On Inflammation In War Against Type 1 Diabetes

July 2007

Insulin Capsules Have Potential To Prevent Diabetes Before Symptoms Appear And Treat The Disease In Its Later Stages

Refining basal insulin therapy: what have we learned in the age of analogues?

Influence of glycemic variables on hemoglobin a1c.

New Type 1 Diabetes Gene Found In Children

Comparison between basal insulin glargine and NPH insulin in patients with diabetes type 1 on conventional intensive insulin therapy

May/June 2007

 Pancreatic islet transplantation, what has been achieved since
Edmonton break-through

Novel Delivery Method Of Insulin Gene To Combat Juvenile Diabetes Developed

Oral Insulin To Prevent Type 1 Diabetes Tested By Study

Three-yr follow-up of a type 1 diabetes mellitus patient with an islet xenotransplant

Diabetes Linked To Male Infertility

Queen's Research Shows Diabetes Damages Sperm And May Affect Fertility

Significant Strides Being Made Against Diabetic Retinopathy

Disposable Insulin Nanopump from Debiotech and STMicroelectronics Marks Major Breakthrough in Diabetes Treatment

April 2007

The Role of Parental Monitoring in Adolescent Health Outcomes:
Impact on Regimen Adherence in Youth with Type 1 Diabetes.

Seeking the Factors Predisposing to Local Skin Inflammatory State
Development in Children with Type 1 Diabetes (T1DM) Treated with
Continuous Subcutaneous Insulin Infusion (CSII).

Pancreatic Cells Show Variable Plasticity

 Type I diabetics live without insulin in stem cell experiment

Stem Cells -- a Possible Cure for Diabetes

Shorter remission period in young versus older children with diabetes mellitus type 1.

Novel Peptide Could Boost Availability And Success Of Islet Cell Transplant For Type-1 Diabetes

Diamyd Medical Announces Phase III Clinical Trials Plan For Diamyd(R) In Type 1 Diabetes

Protein Makes It Possible For High Blood Glucose To Enter Embryonic Cells

Successful Islet Cell Transplant Without Immunosuppressive Therapy In Mice With Type 1 Diabetes

March 2007

Defective Awakening Response to Nocturnal Hypoglycemia in Patients with Type 1 Diabetes Mellitus

Awakening from Sleep and Hypoglycemia in Type 1 Diabetes Mellitus

The relationship between ACE genotype and risk of severe hypoglycaemia in a large population-based cohort of children and adolescents with type 1 diabetes.
 

Classification of Distinct Baseline Insulin Infusion Patterns in Children and Adolescents With Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion Therapy

Perceptions of Psychosocial Factors and the Insulin Pump

School performance in children with type 1 diabetes-a population-based register study

Chronic Care Model Associated with Improved Diabetic Control

February 2007

Study Tests Oral Insulin to Prevent Type 1 Diabetes

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Mom's Stem Cells Might Treat Child's Diabetes

January 2007

Phase II/III Clinical Trial Of Anti-CD3 Monoclonal Antibody For Children And Adults With Recent-Onset Type 1 Diabetes

Antibody Therapy Prevents Type 1 Diabetes In Mice

December 2006

Immune Responses Spread From One Protein To Another In Type 1 Diabetes

The effects of acute hypoglycaemia on memory acquisition and recall and prospective memory in type 1 diabetes.

Research Yields New Insights Into The Cause Of Diabetes

Treatment of new-onset type 1 diabetes with peptide DiaPep277(R) is safe and associated with preserved beta-cell function: extension of a
randomized, double-blind, phase II trial.

The prevalence of depression and anxiety in adults with Type 1
diabetes

New Data From NIH Lab Confirms Protocol To Reverse Type 1 Diabetes In Mice

October 2006

MacroGenics Receives Orphan Drug Designation From FDA For Monoclonal Antibody To Treat Type 1 Diabetes

Researchers Eye Artificial Pancreas

Pancreatic Islet Transplantation  An interesting article explaining islet transplant therapy.

Diabetics get transplanted cells and eliminate the need for insulin shots

Edmonton Protocol Clinical Trial Findings Show Promise For Certain Patients With Severe Type 1 Diabetes

Important news for those diagnosed with neonatal type 1 diabetes...Targeted Therapy Turns Life Around For Child With Neonatal Diabetes

September 2006

Tight Control of Type 1 Diabetes: Recommendations for Patients

Researchers Uncover Gene That Raises Risk for Type 1 Diabetes

Microencapsulation of living cells to treat diabetes? Austrianova validates commercial potential of its proprietary encapsulation technology.

Therapy Insight: the impact of type 1 diabetes on brain development and function.

Summer 2006

Managing insulin therapy during exercise in type 1 diabetes mellitus.

Adult Stem Cell Research Breakthrough Produces Insulin for Diabetics

Researchers Find Glycemic Index Effective In Composite Meals, University Of Toronto

June 2006

Lilly, Alkermes: AIR insulin shown effective
Drug in development as treatment for Type I, Type II diabetes

Physical Activity Linked To Improved Glucose Control In Children With Type 1 Diabetes

May 2006

New study reveals signaling pathways required for expansion of pancreas stem cells

Hypoglycemia Preceding Fatal Car Collisions

Mixing Lantus with fast analogs has no effect on control 

February 2006

Type 1 Diabetes Tied to Thinner Bones.  Study: Women With Type 1 Diabetes May Need Early Bone Density Test

January 2006

Low Blood Sugar and Memory

New generation of insulin pump - Starbridge secures global diabetes contract

December 2005

Getting a diabetic pancreas to regrow its islets

In New Zealand Pig cell diabetes treatment debated

New generation of insulin pump - Starbridge secures global diabetes contract

November 2005 

Diabetes findings pinpoint those at greater risk

October 2005

SA study finds diabetics' natural defence

July 2005

Tiny pump could transform lives

Joslin-Chaired Study Shows New Compound May Reduce Risk Of Vision Loss In Patients With Diabetes   New study shows that 32 milligrams per day of ruboxistaurin (RBX) may reduce the risk of moderate vision loss, especially in patients with diabetic macular edema.

May 2005

Hyperglycemia Slows Mental Functions.

Int J Clin Pract Suppl. 2002 Jul(129):20-6. Related Articles, Links The effects of glucose fluctuation on cognitive function and QOL: the functional costs of hypoglycaemia and hyperglycaemia among adults with type 1 or type 2 diabetes.Cox D, Gonder-Frederick L, McCall A, Kovatchev B, Clarke W.University of Virginia, Charlottesville, USA. Publication Types: * Review * Review, Tutorial PMID: 12166601 [PubMed - indexed for MEDLINE]

J Pediatr Endocrinol Metab. 1996 Jul-Aug;9(4):455-61. Acute hyperglycaemia impairs cognitive function in children with IDDM.

Diabetes Care. 1999 Aug;22(8):1318-24. Comment in: * Diabetes Care. 1999 Aug;22(8):1239-41.Conventional versus intensive diabetes therapy in children with type 1 diabetes: effects on memory and motor speed.  

Physiol Behav. 1998 Jul;64(5):653-60. Related Articles, Links 
Effect of acute hypoglycemia on visual information processing in adults with type 1 diabetes mellitus.

Neurocognitive functioning in children with type-1 diabetes with and without episodes of severe hypoglycaemia  Dev Med Child Neurol. 2003 Apr;45(4):262-8.

Severe hypoglycemia and long-term spatial memory in children with type 1 diabetes mellitus: a retrospective study

Hypoglycemia in children with type 1 diabetes: current issues and controversies

Nocturnal hypoglycemia detected with the Continuous Glucose Monitoring System in pediatric patients with type 1 diabetes
J Pediatr. 2002 Nov;141(5):625-30
 

Decreased consciousness of hypoglycaemia and the incidence of severe hypoglycaemia in children and adolescents with diabetes type 1

The Impact of Severe Hypoglycemia and Impaired Awareness of Hypoglycemia on Relatives of Patients With Type 1 Diabetes

The best defense against hypoglycemia is to recognize it: is caffeine useful? Watson J, Kerr D. Bournemouth Diabetes and Endocrine Centre, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, United Kingdom.  Caffeine may increase an individual's sensitivity to hypoglycemia through the combined effects of reducing substrate delivery to the brain via constriction of the cerebral arteries, whilst simultaneously increasing brain glucose metabolism and augmenting catecholamine production

Hyperglycemia Slows Mental Functions in People with Diabetes

Quality of life in school-aged children with type 1 diabetes on intensive treatment and their parents
Whittemore R, Urban AD, Tamborlane WV, Grey M

April 2005

Human blood cells coaxed to produce insulin  

March 2005

Single-Donor, Marginal-Dose Islet Transplantation in Patients With Type 1 Diabetes 

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